Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …

Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-
malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

Apicomplexans and related lineages comprise many obligate symbionts of animals; some of
which cause notorious diseases such as malaria. They evolved from photosynthetic …

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to
limitations in the throughput of phenotyping at these stages. To fill this gap, we followed …

Fatty acid (FA) biosynthesis plays a central role in the metabolism of living cells as building
blocks of biological membranes, energy reserves of the cell, and precursors to second …

The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the
ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways …

Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle
in Plasmodium falciparum malaria parasites and is required for prenylation-dependent …