Endogenous opioid systems alterations in pain and opioid use disorder

JA Higginbotham, T Markovic, N Massaly… - Frontiers in systems …, 2022 - frontiersin.org
Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …

Animal models of fibromyalgia: What is the best choice?

ES Brum, G Becker, MFP Fialho, SM Oliveira - Pharmacology & …, 2022 - Elsevier
Fibromyalgia (FM) is a complex syndrome, with an indefinite aetiology and intricate
pathophysiology that affects 2–3% of the world population. From the beginning of the 2000s …

Integrated metabolomics revealed the fibromyalgia-alleviation effect of Mo2C nanozyme through regulated homeostasis of oxidative stress and energy metabolism

D Zhang, L Jiang, L Li, X Li, W Zheng, L Gui, Y Yang… - Biomaterials, 2022 - Elsevier
Fibromyalgia (FM), the most common cause of chronic musculoskeletal pain in the general
public, lacks advanced therapeutic methodology and detailed bioinformation. However …

Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model

ES Brum, MFP Fialho, SPM Fischer, DD Hartmann… - Molecular …, 2020 - Springer
Fibromyalgia (FM) is one of the most common musculoskeletal pain conditions. Although the
aetiology of FM is still unknown, mitochondrial dysfunction and the overproduction of …

[HTML][HTML] The antinociceptive effects and sex-specific neurotransmitter modulation of metformin in a mouse model of fibromyalgia

HA AboTaleb, HA Alturkistani, GS Abd El-Aziz… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Fibromyalgia (FM) is a chronic and debilitating condition characterized by diffuse pain, often
associated with symptoms such as fatigue, cognitive disturbances, and mood disorders …

Long-lasting nociplastic pain modulation by repeated administration of sigma-1 receptor antagonist BD1063 in fibromyalgia-like mouse models

B Álvarez-Pérez, A Bagó-Mas, M Deulofeu… - International Journal of …, 2022 - mdpi.com
Sigma-1 receptor (σ1R) ligands have been shown to be effective at relieving neuropathic
and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia …

[HTML][HTML] Differential glucose and beta-hydroxybutyrate metabolism confers an intrinsic neuroprotection to the immature brain in a rat model of neonatal hypoxia …

FK Odorcyk, LE Duran-Carabali, DS Rocha… - Experimental …, 2020 - Elsevier
Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity.
Preclinical studies have shown that the immature rat brain is more resilient to HI injury …

[HTML][HTML] Evaluation of reserpine-induced fibromyalgia in mice: A comparative behavioral, neurochemical, and histological assessment of two doses

H AboTaleb, EA Hindi, GS Abd El-Aziz… - IBRO Neuroscience …, 2024 - Elsevier
Fibromyalgia (FM) is a chronic pain disorder characterised by widespread musculoskeletal
pain, fatigue, and cognitive disturbances. Due to its complex and poorly understood …

Induction of orofacial pain potentiates fibromyalgia symptoms in mice: Relevance of nociceptin system

MCC Volkweis, LA Tomasi, GC Santos, APA Dagnino… - Life Sciences, 2024 - Elsevier
Aims Fibromyalgia patients might experience temporomandibular disorder (TMD) as a
comorbidity. However, the connection between these two syndromes is not fully understood …

Magnesium hexacyanoferrate nanocatalysts alleviates fibromyalgia syndrome by reversing cellular ferroptosis

L Jiang, Z Zhu, K Han, D Chen, L Huang, N Hu… - Chemical Engineering …, 2024 - Elsevier
Fibromyalgia (FM), the most common causes of chronic musculoskeletal pain, is a complex
syndrome with an indefinite etiology. Ferroptosis is a new type of cell death characterized by …