Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials,
chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health …

The emergence and spread of antimalarial resistance has been a major liability for malaria
control. The spread of chloroquine-resistant Plasmodium falciparum strains had catastrophic …

Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …

The widespread use of chloroquine to treat P lasmodium falciparum infections has resulted
in the selection and dissemination of variant haplotypes of the primary resistance …

Artemisinin-based combination therapy for malaria has become widely available across
Africa. Populations of Plasmodium falciparum that were previously dominated by …

Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum
(Pf crt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance …

Background Effective treatment remains a mainstay of malaria control, but it is unfortunately
strongly compromised by drug resistance, particularly in Plasmodium falciparum, the most …

Background Chloroquine combined with primaquine has been the recommended
antimalarial treatment of Plasmodium vivax malaria infections for six decades but the …

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs
such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health …

Background Effective malaria control programs require continuous monitoring of drug
pressure in the field, using molecular markers Methods We used sequence analysis to …