The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

The last five years have witnessed a remarkable renaissance in vitamin D research and a
complete re-evaluation of its benefits to human health. Two key factors have catalyzed these …

Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …

The mitochondrial enzyme 25-hydroxyvitamin D3-1α-hydroxylase (1α-hydroxylase) plays an
important role in calcium homeostasis by catalyzing synthesis of the active form of vitamin D …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

Recent research activities have provided new insights in vitamin D metabolism in various
conditions. Furthermore, substantial progress has been made in the analysis of vitamin D …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in
part is associated with gelatinase from neutrophils. This protein shows a high degree of …

Circulating levels of 25-hydroxyvitamin D (25 (OH) D) are the most commonly used marker
for the assessment of vitamin D nutritional status. The main reason why 25 (OH) D levels are …