[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics

MJ Peluso, SG Deeks - Cell, 2024 - cell.com
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness

P Pandharipande, SW Roberson… - The Lancet …, 2023 - thelancet.com
Despite advances in the treatment and mitigation of critical illness caused by infection with
SARS-CoV-2, millions of survivors have a devastating, post-acute infection syndrome known …

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

RC Thompson, NW Simons, L Wilkins, E Cheng… - Nature Medicine, 2023 - nature.com
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles

T Aschman, E Wyler, O Baum, A Hentschel… - Acta Neuropathologica …, 2023 - Springer
The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but
also in many cases of post-infectious syndromes, colloquially referred to as “long COVID” …

Overview of autoantibodies in COVID‐19 convalescents

K Dobrowolska, D Zarębska‐Michaluk… - Journal of medical …, 2023 - Wiley Online Library
Accumulating evidence shows that SARS‐CoV‐2 can potentially trigger autoimmune
processes, which can be responsible for the long‐term consequences of COVID‐19 …

Increased incidence of rheumatoid arthritis after COVID-19

JS Marín, EA Mazenett-Granados… - Autoimmunity …, 2023 - Elsevier
An increase in the incidence of inflammatory arthritis after COVID-19 has been reported.
Since many diseases exhibit population-specific causal effect sizes, we aimed to evaluate …

Immune response and molecular mechanisms of cardiovascular adverse effects of spike proteins from SARS-CoV-2 and mRNA vaccines

P Bellavite, A Ferraresi, C Isidoro - Biomedicines, 2023 - mdpi.com
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the
COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells …

[HTML][HTML] Mitogen activated protein kinase (MAPK) activation, p53, and autophagy inhibition characterize the severe acute respiratory syndrome coronavirus 2 (SARS …

AM Kyriakopoulos, G Nigh, PA McCullough, S Seneff - Cureus, 2022 - ncbi.nlm.nih.gov
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and
prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions …

Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach

DLM Fonseca, IS Filgueiras, AHC Marques, E Vojdani… - npj Aging, 2023 - nature.com
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to
immunosenescence and certain age-dependent medical conditions (eg, obesity …

[HTML][HTML] Biological mechanisms underpinning the development of long COVID

R Perumal, L Shunmugam, K Naidoo, D Wilkins… - Iscience, 2023 - cell.com
As COVID-19 evolves from a pandemic to an endemic disease, the already staggering
number of people that have been or will be infected with SARS-CoV-2 is only destined to …