Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

Ferroptosis-a new target of osteoporosis

Z Gao, Z Chen, Z Xiong, X Liu - Experimental gerontology, 2022 - Elsevier
Osteoporosis is a bone metabolic disease characterized by reduced bone mass and
deterioration of bone tissue microarchitecture, leading to enhanced skeletal fragility and …

The role of trace elements and minerals in osteoporosis: a review of epidemiological and laboratory findings

AV Skalny, M Aschner, EV Silina, VA Stupin… - Biomolecules, 2023 - mdpi.com
The objective of the present study was to review recent epidemiological and clinical data on
the association between selected minerals and trace elements and osteoporosis, as well as …

Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model

ZS Tao, TL Li, S Wei - Chemico-Biological Interactions, 2022 - Elsevier
Silibinin (SIL) has been used extensively for its hepatoprotective properties and antioxidant
properties, including bone health. Iron overload can inhibit osteogenic proliferation and …

Iron overload induced osteocytes apoptosis and led to bone loss in Hepcidin−/− mice through increasing sclerostin and RANKL/OPG

J Ma, A Wang, H Zhang, B Liu, Y Geng, Y Xu, G Zuo… - Bone, 2022 - Elsevier
Background Numerous studies have demonstrated that iron overload is a risk factor of
osteoporosis. However, there has been no systematic and in-depth studies on the effect of …

Research progress of ferroptosis regulatory network and bone remodeling in osteoporosis

C Yan, J Zhang, F An, J Wang, Y Shi, L Yuan… - Frontiers in Public …, 2022 - frontiersin.org
Ferroptosis was induced the programmed cell death with iron overload Fenton reaction.
Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that …

Repair and regeneration: ferroptosis in the process of remodeling and fibrosis in impaired organs

J Yin, X Xu, Y Guo, C Sun, Y Yang, H Liu, P Yu… - Cell Death …, 2024 - nature.com
As common clinical-pathological processes, wound healing and tissue remodelling
following injury or stimulation are essential topics in medical research. Promoting the …

Sirtuins mediate mitochondrial quality control mechanisms: a novel therapeutic target for osteoporosis

T Zhang, L Wang, X Duan, Y Niu, M Li, L Yun… - Frontiers in …, 2024 - frontiersin.org
Mitochondria plays a role in cell differentiation and apoptosis processes. Maintaining
mitochondrial function is critical, and this involves various aspects of mitochondrial quality …

Associations of copper intake with bone mineral density and osteoporosis in adults: data from the national health and nutrition examination survey

Y Fan, S Ni, H Zhang - Biological Trace Element Research, 2022 - Springer
Some studies have suggested an association between serum copper and bone density. Few
studies have explored the association between copper intake and osteoporosis and bone …