Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation

Q Chi, T Xu, Y He, Z Li, X Tang, X Fan, S Li - Journal of Hazardous Materials, 2022 - Elsevier
The widespread use of plastics and the rapid development of nanotechnology bring
convenience to our lives while also increasing the environmental burden and increasing the …

Neutrophil extracellular traps enriched with IL-1β and IL-17A participate in the hepatic inflammatory process of patients with non-alcoholic steatohepatitis

S Arelaki, T Koletsa, E Sinakos, V Papadopoulos… - Virchows Archiv, 2022 - Springer
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of various non-
infectious inflammatory and thrombotic diseases. We investigated the presence and …

Diverse epigenetic regulations of macrophages in atherosclerosis

H Yang, Y Sun, Q Li, F Jin, Y Dai - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Emerging research on epigenetics has resulted in many novel discoveries in atherosclerosis
(AS), an inflammaging-associated disease characterized by chronic inflammation primarily …

Neutrophil subsets in noncancer liver diseases: Cellular crosstalk and therapeutic targets

C Huang, X Fan, Y Shen, M Shen… - European Journal of …, 2023 - Wiley Online Library
Neutrophils are the most abundant circulating granulocytes, linking innate and adaptive
immunity. Neutrophils can regulate inflammatory and immune responses through …

Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: a narrow review

TM Yang, M Miao, WQ Yu, X Wang, FJ Xia… - Frontiers in Molecular …, 2023 - frontiersin.org
Macrophages are involved in the whole process of atherosclerosis, which is characterized
by accumulation of lipid and inflammation. Presently, clinically used lipid-lowering drugs …

Cholinergic Polarization of Human Macrophages

N Roa-Vidal, AS Rodríguez-Aponte… - International Journal of …, 2023 - mdpi.com
Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular
adaptability in response to invading pathogens and various stimuli. These cells express …

Pathological significance of macrophages in erectile dysfunction including Peyronie's disease

Y Miyata, T Matsuo, Y Nakamura, K Mitsunari, K Ohba… - Biomedicines, 2021 - mdpi.com
Erectile function is regulated by complex mechanisms centered on vascular-and nerve-
related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED) …

The PD-1/PD-L1 Axis in the Biology of MASLD

RM Pipitone, G Lupo, R Zito, A Javed, S Petta… - International Journal of …, 2024 - mdpi.com
Metabolic Dysfunction-Associated Steatotic Liver (MASL), previously named nonalcoholic
fatty liver (NAFL), is a multifactorial disease in which metabolic, genetic, and environmental …