Targeting p53 pathways: mechanisms, structures, and advances in therapy
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …
been a major focus of oncology research. The p53 protein is a transcription factor that can …
[HTML][HTML] Targeting p53 for the treatment of cancer
MJ Duffy, NC Synnott, S O'Grady, J Crown - Seminars in cancer biology, 2022 - Elsevier
Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …
Mutant p53 in cancer progression and targeted therapies
G Zhu, C Pan, JX Bei, B Li, C Liang, Y Xu, X Fu - Frontiers in oncology, 2020 - frontiersin.org
TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …
Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
Drugging “undruggable” genes for cancer treatment: Are we making progress?
MJ Duffy, J Crown - International journal of cancer, 2021 - Wiley Online Library
Abstract RAS, TP53 (p53) and MYC are among the most frequently altered driver genes in
cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently …
cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently …
COTI-2, a novel thiosemicarbazone derivative, exhibits antitumor activity in HNSCC through p53-dependent and-independent mechanisms
A Lindemann, AA Patel, NL Silver, L Tang, Z Liu… - Clinical Cancer …, 2019 - AACR
Purpose: TP 53 mutations are highly prevalent in head and neck squamous cell carcinoma
(HNSCC) and associated with increased resistance to conventional treatment primarily …
(HNSCC) and associated with increased resistance to conventional treatment primarily …
The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy
Y Liu, X Wang, G Wang, Y Yang, Y Yuan… - European journal of …, 2019 - Elsevier
The p53 gene, a well-known tumor suppressor gene, plays a crucial role in cell cycle
regulation, DNA repair, cell differentiation, and apoptosis. MDM2 exerts p53-dependent …
regulation, DNA repair, cell differentiation, and apoptosis. MDM2 exerts p53-dependent …
Advanced strategies for therapeutic targeting of wild-type and mutant p53 in cancer
TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding
transcription factor activated by stressful stimuli; it upregulates target genes involved in …
transcription factor activated by stressful stimuli; it upregulates target genes involved in …
Major molecular signaling pathways in oral cancer associated with therapeutic resistance
Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …