Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors
Abstract New series of triazolo [4, 3-c] quinazolines were designed, synthesized and their
structures were elucidated using different spectroscopic techniques. They were evaluated …
structures were elucidated using different spectroscopic techniques. They were evaluated …
Exploring of tumor-associated carbonic anhydrase isoenzyme IX and XII inhibitory effects and cytotoxicities of the novel N-aryl-1-(4-sulfamoylphenyl)-5-(thiophen-2-yl) …
A series of novel N-aryl-1-(4-sulfamoylphenyl)-5-(thiophen-2-yl)-1H-pyrazole-3-
carboxamides was synthesized and examined as inhibitors of cytosolic (human) hCA I and …
carboxamides was synthesized and examined as inhibitors of cytosolic (human) hCA I and …
The design, synthesis, and biological activities of pyrrole-based carboxamides: the novel tubulin inhibitors targeting the colchicine-binding site
S Boichuk, A Galembikova, K Syuzov, P Dunaev… - Molecules, 2021 - mdpi.com
Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic
spindle are well-known and effective chemotherapeutic agents. These agents interrupt the …
spindle are well-known and effective chemotherapeutic agents. These agents interrupt the …
Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation
L Ma, K Zhang, Z Huang, Y Guo, N Liu… - Journal of Medicinal …, 2024 - ACS Publications
Recent advances in targeted protein degradation (TPD) have propelled it to the forefront of
small molecular drug discovery. Among these, hydrophobic tagging (HyT) strategies have …
small molecular drug discovery. Among these, hydrophobic tagging (HyT) strategies have …
[HTML][HTML] Механизмы цитотоксической активности пирролкарбоксамидов в отношении опухолевых клеточных сублиний с множественной лекарственной …
АР Галембикова, ПД Дунаев… - Успехи …, 2023 - cyberleninka.ru
Введение. Вещества, именуемые митотическими ядами и влияющие на динамическое
состояние микротрубочек веретена деления, являются хорошо известными и …
состояние микротрубочек веретена деления, являются хорошо известными и …
Discovery of 7-bromo-1, 4-dihydrothieno [3', 2': 5, 6] thiopyrano [4, 3-c] pyrazole-3-carboxamide derivatives as the potential epidermal growth factor receptors for …
Q Xie, J Wang, M Liu, X Wang, D Jiao, Q Ma… - Medicinal Chemistry …, 2019 - Springer
Small molecule tyrosine kinase inhibitors (TKIs) targeting at epidermal growth factor receptor
(EGFR) in recent years have made great progress in the treatment of advanced non-small …
(EGFR) in recent years have made great progress in the treatment of advanced non-small …
Design, Synthesis and Biological Evaluation of a New Series of 1-Aryl-3-{4-[(pyridin-2-ylmethyl) thio] phenyl} urea Derivatives as Antiproliferative Agents
C Zhang, X Tan, J Feng, N Ding, Y Li, Z Jin, Q Meng… - Molecules, 2019 - mdpi.com
To discover new antiproliferative agents with high efficacy and selectivity, a new series of 1-
aryl-3-{4-[(pyridin-2-ylmethyl) thio] phenyl} urea derivatives (7a–7t) were designed …
aryl-3-{4-[(pyridin-2-ylmethyl) thio] phenyl} urea derivatives (7a–7t) were designed …