In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …

Cancer is one of the major causes of death and a significant obstacle to increasing life
expectancy worldwide. Chemotherapy remains the first-line adjuvant therapeutic option for …

Mitochondria, organelles that harbor their own circular genomes, are critical for energy
production and homeostasis maintenance in eukaryotic cells. Recent studies discovered …

The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood
compared to coding transcripts. We recently identified ZC3H4-WDR82 (" restrictor") as …

Colorectal cancer (CRC) is one of the most frequent cancers in incidence and mortality.
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …

Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily
attributed to the persistent infection of high-risk Human papillomavirus (HPV). Despite …

LncRNAs play a critical role in oral squamous cell carcinoma (OSCC) progression.
However, the function and detailed molecular mechanism of most lncRNAs in OSCC are not …

Neural invasion (NI) is a vital pathological characteristic of gastric cancer (GC), which
correlates with tumor recurrence and a worse prognosis. Long noncoding RNAs (lncRNAs) …