For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

Human aging is characterized by large differences between and within older adults.
Numerous factors are known to contribute to these differences, including genetic and …

The world population increases every day as a consequence of the increase in life
expectancy and longevity of humans. There are several factors analyzed in the different …

Structural equation model (SEM) trees, a combination of SEMs and decision trees, have
been proposed as a data-analytic tool for theory-guided exploration of empirical data. With …

The Barcelona Brain Health Initiative (BBHI) is an ongoing prospective longitudinal study
focused on identifying determinants of brain health. The main objectives are:(i) to …

Background Biomarkers of psychiatric treatment response remain elusive. Functional
magnetic resonance imaging (fMRI) has shown promise, but low reliability has limited the …

From a biological perspective, humans differ in the speed they age, and this may manifest in
both mental and physical health disparities. The discrepancy between an individual's …

Subjective well-being is often characterized by average stability across old age, but
individual differences are substantial and not yet fully understood. This study targets …

The fact that tyrosine increases dopamine availability that, in turn, may enhance cognitive
performance has led to numerous studies on healthy young participants taking tyrosine as a …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …