The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine
(decitabine) are the currently most advanced drugs for epigenetic cancer therapies. These …

Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the
rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS …

Introduction: The majority of patients with acute myeloid leukemia (AML) are older and
exhibit a poor prognosis even after intensive therapy. Inducing differentiation and apoptosis …

The purine nucleoside analogs (PNA) form an important group of cytotoxic drugs active in
the treatment of neoplastic and autoimmune diseases. Three of them, fludarabine (FA) …

A characteristic shared by most frequent types of primary liver cancer, ie, hepatocellular
carcinoma (HCC) and cholangiocarcinoma (CCA) in adults, and in a lesser extent …

Nucleosides are required for DNA and RNA synthesis, and the nucleoside adenosine has a
function in a variety of signalling processes,. Transport of nucleosides across cell …

Abstract Cladribine Tablets (MAVENCLAD®) are used to treat relapsing multiple sclerosis
(MS). The recommended dose is 3.5 mg/kg, consisting of 2 annual courses, each comprising …

Some nucleoside analogues currently used as antiretroviral agents might promote
mutagenesis besides their putative ability to interfere with endogenous nucleotide …

Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent
therapeutic agents since their introduction in 1950, deployed widely in the treatment of …

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric
complex that senses intracellular energy status and exerts rapid regulation on energy …