Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Alzheimer's disease has become a major public health issue. While extensive research has
been conducted in the last few decades, few drugs have been approved by the FDA to treat …

Alzheimer's disease is a chronic and degenerative condition that had no treatment until
recently. The current therapeutic strategies reduce progression of the disease but are …

Abstract Background Recent research in Alzheimer's disease (AD) field has been focused
on the potential role of the amyloid-β protein that is derived from the transmembrane amyloid …

The use of lithium is well established in bipolar disorders and the benefits are being
demonstrated in neurodegenerative disorders. Recently, our group showed that treatment …

Neuropeptides are small proteins broadly expressed throughout the central nervous system,
which act as neurotransmitters, neuromodulators and neuroregulators. Growing evidence …

No cure or disease-modifying therapy for Alzheimer's disease (AD) has yet been realized.
However, a multitude of pharmacological targets have been identified for possible …

The Kallikrein-Kinin System (KKS) has been associated to inflammatory and immunogenic
responses in the peripheral and central nervous system by the activation of two receptors …

A better understanding of Alzheimer's disease (AD) and the development of disease
modifying therapies are some of the biggest challenges of the 21st century. One of the core …

The deposition of amyloid-β peptides (Aβ) in the cerebral vasculature, a condition known as
cerebral amyloid angiopathy, is increasingly recognized as an important component leading …