Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

Post-translational modifications (PTMs) produce significant changes in the structural
properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …

Cell signaling that culminates in posttranslational modifications directs protein activity. Here
we report how multiple Ca2+-dependent phosphorylation sites within the transcription …

Cooperative DNA-binding by transcription factor (TF) proteins is critical for eukaryotic gene
regulation. In the human genome, many regulatory regions contain TF-binding sites in close …

The E26 transformation-specific (ETS) family of transcription factors is critical for
development, differentiation, proliferation and also has a role in apoptosis and tissue …

Ets factors are members of one of the largest families of evolutionarily conserved
transcription factors, regulating critical functions in normal cell homeostasis, which when …