Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Importance Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that
increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease …

For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

Introduction: Plasma glial fibrillary acidic protein (GFAP) may be associated with amyloid
burden, neurodegeneration, and stroke but its specificity for Alzheimer's disease (AD) in the …

Background Plasma assays for the detection of Alzheimer's disease neuropathological
changes are receiving ever increasing interest. The concentration of plasma glial fibrillary …

Abstract Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial
activation in the central nervous system (CNS). We previously demonstrated the crucial …

Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer's disease (AD)
patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic …

A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …