Among the various expression systems employed for the over-production of proteins,
bacteria still remains the favorite choice of a Protein Biochemist. However, even today, due …

Recent findings concerning the biology of IFN-λs and their pathophysiological roles in viral
infection, cancer, and immune responses of the innate and adaptive arms are summarized …

Expression as inclusion bodies in Escherichia coli is a widely used method for the large‐
scale production of therapeutic proteins that do not require post‐translational modifications …

PEGylation is the covalent conjugation of PEG to therapeutic molecules. Protein PEGylation
is a clinically proven approach for extending the circulation half-life and reducing the …

The efficacy of protein-based medicines can be compromised by their rapid clearance from
the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for …

Site-selective conjugation generally requires both (i) molecular engineering of the protein of
interest to introduce a conjugation site at a defined location and (ii) a site-specific …

Current research focuses on the soluble and high-level expression of biologically active
recombinant human IL-29 protein in Escherichia coli. The codon-optimized IL-29 gene was …

Escherichia coli has many advantages as a microbial platform for industrial applications.
This chapter summarizes a few examples of E. coli metabolic engineering efforts reported in …

Dermatopontin (DPT) is an extracellular matrix (ECM) protein with diversified
pharmaceutical applications. It plays important role in cell adhesion/migration, angiogenesis …

Microbial culture collections are crucial resource centres providing microbial materials. They
act as repositories for microbial strains as part of patent deposits, confidential services to …