Highlights•S-adenosyl methionine-dependent methyltransferases are ubiquitous in
nature.•Analogs of S-adenosyl methionine can be produced enzymatically.•Crystallography …

Covering: up to 2017 This review covers the biosynthetic and evolutionary aspects of
lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum …

Ribosomally synthesized and post-translationally modified peptide natural products have
provided many highly unusual scaffolds. This includes the intriguing alkaloids crocagins …

In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and
amino sugar units are linked by an amide bond. The respective condensing enzyme …

The structure of lincomycin A consists of the unusual eight-carbon thiosugar core
methyllincosamide (MTL) decorated with a pendent N-methylprolinyl moiety. Previous …

Modification of the N-and C-termini of peptides enhances their stability against degradation
by exopeptidases. The biosynthetic pathways of many peptidic natural products feature …

The immediate post-condensation steps in lincomycin biosynthesis are reminiscent of the
mycothiol-dependent detoxification system of actinomycetes. This machinery provides the …

EgtD is an S-adenosyl-l-methionine (SAM)-dependent histidine N, N, N-methyltransferase
that catalyzes the formation of hercynine from histidine in the ergothioneine biosynthetic …

Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently,
lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to …

Lincosamides such as lincomycin A, celesticetin, and Bu‐2545, constitute an important
group of antibiotics. These natural products are characterized by a thiooctose linked to al …