Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

Mammalian MSC from selected species: Features and applications

C Uder, S Brückner, S Winkler… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of
different diseases in humans and in animals. Following the guidelines of the International …

The gap between the physiological and therapeutic roles of mesenchymal stem cells

U Galderisi, A Giordano - Medicinal research reviews, 2014 - Wiley Online Library
Several investigators have cultivated marrow stromal cells and have identified a population
of mesenchymal stem cells (MSCs). These cells expand extensively in vitro and exhibit …

Epigenetic changes in mesenchymal stem cells differentiation

I Mortada, R Mortada - European journal of medical genetics, 2018 - Elsevier
Epigenetic factors are known to play a major role in determining stem cell fate and
differentiation. Mesenchymal stem cells are the most studied population of stem cells due to …

Role of microRNA shuttled in small extracellular vesicles derived from mesenchymal stem/stromal cells for osteoarticular disease treatment

E Lara-Barba, MJ Araya, CN Hill… - Frontiers in …, 2021 - frontiersin.org
Osteoarticular diseases (OD), such as rheumatoid arthritis (RA) and osteoarthritis (OA) are
chronic autoimmune/inflammatory and age-related diseases that affect the joints and other …

Characterization and classification of mesenchymal stem cells in several species using surface markers for cell therapy purposes

H Ghaneialvar, L Soltani, HR Rahmani, AS Lotfi… - Indian Journal of Clinical …, 2018 - Springer
Mesenchymal stem cells are multipotent cells capable of replicating as undifferentiated cells,
and have the potential of differentiating into mesenchymal tissue lineages such as …

The impact of epigenetics on mesenchymal stem cell biology

Y Ozkul, U Galderisi - Journal of Cellular Physiology, 2016 - Wiley Online Library
Changes in epigenetic marks are known to be important regulatory factors in stem cell fate
determination and differentiation. In the past years, the investigation of the epigenetic …

Evaluation of enzymatic protocols to optimize efficiency of bovine adipose tissue-derived mesenchymal stromal cell isolation

E Heyman, B Devriendt, E De Vlieghere… - npj Science of …, 2024 - nature.com
Sustainable food provision for a continuously growing human population is one of the major
challenges for the next decades. Cultured meat represents one of the alternatives which is …