Transcribed ultraconserved regions in cancer

MK Gibert Jr, A Sarkar, B Chagari, C Roig-Laboy… - Cells, 2022 - mdpi.com
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from
DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as …

Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers

JC Oliveira - Genetics and molecular biology, 2023 - SciELO Brasil
The ultraconserved regions (UCRs) are 481 genomic elements, longer than 200 bp, 100%
conserved in human, mouse, and rat genomes. Usually, coding regions are more …

Lnc-uc. 147 is associated with disease stage of liver, gastric, and renal cancer

AC Rodrigues, EP Zambalde, DL Bellan, ES Trindade… - Biomolecules, 2023 - mdpi.com
Lnc-uc. 147, a long non-coding RNA derived from a transcribed ultraconserved region (T-
UCR), was previously evidenced in breast cancer. However, the role of this region in other …

Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway

Y Xing, Y Lin, Y Zhang, J Hu, J Liu, Y Tian, J Zhao… - Cell Death & …, 2021 - nature.com
NF-κB signaling pathway is a critical link between inflammation and cancer. Emerging
evidence suggested that long non-coding RNAs (lncRNAs) were involved in dysregulation …

Ultra-conserved RNA: A novel biological tool with diagnostic and therapeutic potential

T Wang, F Li, Z Lu - Discover Oncology, 2023 - Springer
Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved
among mice, rats and humans. UcRNA has attracted extensive attention in recent years for …

The dark matter of the human genome and its role in human cancers

I Bozgeyik - Gene, 2022 - Elsevier
The transcribed ultra-conserved regions (T-UCRs) are a novel family of non-coding RNAs
which are absolutely conserved (100%) across orthologous regions of the human, mouse …

Transcribed ultraconserved regions are associated with clinicopathological features in breast cancer

EP Zambalde, D Adamoski, DF Gradia, I Rabinovich… - Biomolecules, 2022 - mdpi.com
Ultraconserved regions (UCRs) are 481 genome segments, with length longer than 200 bp,
that are 100% conserved among humans, mice, and rats. The majority of UCRs are …

[HTML][HTML] Role of transcribed ultraconserved regions in gastric cancer and therapeutic perspectives

SS Gao, ZK Zhang, XB Wang, Y Ma… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Gastric cancer (GC) is the fourth leading cause of cancer-related death. The occurrence and
development of GC is a complex process involving multiple biological mechanisms …

Regions (T-UCRs) a New Light

M Radanova - Noncoding RNA: The Dark Matter of the Genome, 2024 - books.google.com
Abstract Transcribed Ultra-Conserved Regions (T-UCRs) are a novel class of long non-
coding RNAs derived from Ultra-Conserved Regions (UCRs) of DNA. The discovery of …

[HTML][HTML] Transcribed-Ultra Conserved Regions (T-UCRs) a New Light on a Dark Matter

M Radanova - 2023 - intechopen.com
Abstract Transcribed Ultra-Conserved Regions (T-UCRs) are a novel class of long non-
coding RNAs derived from Ultra-Conserved Regions (UCRs) of DNA. The discovery of …