Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Angiogenesis is involved in maintaining normal physiological processes like embryonic
development, wound healing, inflammation and reproduction. Pathogenesis of various …

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre …

Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes.
Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor …

The study of cancer genes in mouse models has traditionally relied on genetically-
engineered strains made via transgenesis or gene targeting in embryonic stem cells. Here …

Many RNA species have been identified as important players in the development of chronic
diseases, including cancer. Over the past decade, numerous studies have highlighted how …

A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of
central importance. Here we developed an adeno-associated virus–mediated …

We and other groups have demonstrated that exposure to nickel nanoparticles (Nano-Ni)
results in severe and persistent lung inflammation and fibrosis, but the underlying …

The hallmarks of cancer were proposed as a logical framework to guide research efforts that
aim to understand the molecular mechanisms and derive treatments for this highly complex …

Abstract Background Nickel nanoparticles (Nano-Ni) are increasingly used in industry and
biomedicine with the development of nanotechnology. However, the genotoxic and …