Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

Molecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are
insufficiently elucidated. A detailed understanding of these mechanisms may help to further …

Upon postsynaptic glutamate receptor activation, the cytosolic Ca 2+ concentration rises and
initiates signaling and plasticity in spines. The plasma membrane Ca 2+ ATPase (PMCA) is …

Male reproduction depends on hormonally driven behaviors and numerous genes for testis
development and spermatogenesis. Neuroplastin-deficient (Nptn−/−) male mice cannot sire …

The Ca2+ ion is a universal second messenger involved in many vital physiological
functions including cell migration and development. To fulfil these tasks the cytosolic Ca2+ …

The main function of neurons is information transmission in the form of action potentials. To
fulfill this duty, neurons are connected functionally with each other via synapses, the …

Hearing, the ability to sense sounds, and the processing of auditory information are
important for perception of the world. Mice lacking expression of neuroplastin (Np), a type-1 …

Synaptic ribbons are presynaptic specializations that define eponymous ribbon synapses.
Synaptic ribbons are largely composed of RIBEYE, a protein containing an N-terminal A …

The hair bundle of cochlear hair cells comprises specialized microvilli, the stereocilia, which
fulfil the role of mechanotransduction. Genetic defects and environmental noise challenge …

Mouse studies continue to help elaborate upon the genetic landscape of mammalian
disease and the underlying molecular mechanisms. Here, we have investigated an Embigin …