• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Primary aldosteronism is a common cause of secondary hypertension associated with
excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it …

Objective: To develop clinical practice guidelines for the management of patients with
primary aldosteronism. Participants: The Task Force included a chair, selected by the …

An adrenal incidentaloma is now established as a common endocrine diagnosis that
requires a multidisciplinary approach for effective management. The majority of patients can …

Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Primary aldosteronism (PA), the most common form of secondary hypertension, can be
either surgically cured or treated with targeted pharmacotherapy. PA is frequently …

By definition, an adrenal incidentaloma is an asymptomatic adrenal mass detected on
imaging not performed for suspected adrenal disease. In most cases, adrenal …

Adrenal venous sampling is recommended by current guidelines to identify surgically
curable causes of hyperaldosteronism but remains markedly underused. Key factors …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

At least 5% of individuals with hypertension have adrenal aldosterone-producing adenomas
(APAs). Gain-of-function mutations in KCNJ5 and apparent loss-of-function mutations in …