Environmental risk factors for schizophrenia and bipolar disorder and their relationship to genetic risk: current knowledge and future directions

N Robinson, SE Bergen - Frontiers in genetics, 2021 - frontiersin.org
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

Gene-environment interactions in schizophrenia: a literature review

MH Wahbeh, D Avramopoulos - Genes, 2021 - mdpi.com
Schizophrenia is a devastating mental illness with a strong genetic component that is the
subject of extensive research. Despite the high heritability, it is well recognized that non …

Schizophrenia polygenic risk and experiences of childhood adversity: a systematic review and meta-analysis

GE Woolway, SE Smart, AJ Lynham… - Schizophrenia …, 2022 - academic.oup.com
Abstract Background and Hypothesis Schizophrenia has been robustly associated with
multiple genetic and environmental risk factors. Childhood adversity is one of the most …

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

R Plomin, A Gidziela, M Malanchini… - Development and …, 2022 - cambridge.org
The DNA revolution has energized research on interactions between genes and
environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors …

Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum

LK Pries, GA Dal Ferro, J van Os… - Epidemiology and …, 2020 - cambridge.org
AimsPsychosis spectrum disorder has a complex pathoetiology characterised by interacting
environmental and genetic vulnerabilities. The present study aims to investigate the role of …

[HTML][HTML] A compassion-focused ecological momentary intervention for enhancing resilience in help-seeking youth: uncontrolled pilot study

C Rauschenberg, B Boecking, I Paetzold… - JMIR mental …, 2021 - mental.jmir.org
Background: Digital interventions offer new avenues for low-threshold prevention and
treatment in young people. Ecological momentary interventions (EMIs) represent a powerful …

Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia

LK Pries, J Van Os, M Ten Have, R De Graaf… - JAMA …, 2020 - jamanetwork.com
Importance Both adulthood stressful life events (SLEs) and liability for schizophrenia have
been associated with poor mental and physical health in the general population, but their …

Childhood maltreatment and emotion regulation in everyday life: an experience sampling study

A Ion, MI Bîlc, S Pițur, CF Pop, A Szentágotai-Tătar… - Scientific reports, 2023 - nature.com
Childhood maltreatment is a major risk factor for psychopathology, and increasing evidence
suggests that emotion regulation is one of the underlying mechanisms. However, most of …

Polygenic risk for major depression interacts with parental criticism in predicting adolescent depressive symptom development

SA Nelemans, M Boks, B Lin, T Oldehinkel… - Journal of Youth and …, 2021 - Springer
Research has focused more and more on the interplay between genetics and environment
in predicting different forms of psychopathology, including depressive symptoms. While the …

Effect of child abuse and neglect on schizophrenia and other psychotic disorders

BH Chaiyachati, RE Gur - Pharmacology Biochemistry and Behavior, 2021 - Elsevier
Childhood experiences impact long-term physical and behavioral health outcomes including
potential risk for schizophrenia and psychosis. Negative experiences, such as child abuse …