The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …

In Alzheimer's disease (AD), soluble amyloid-β oligomers (AβOs) trigger neurotoxic
signaling, at least partially, via the cellular prion protein (PrPC). However, it is unknown …

The cellular prion protein (PrP C) is a metal-binding biomolecule that can interact with
different protein partners involved in pivotal physiological processes, such as neurogenesis …

Cell adhesion molecules (CAMs) play indispensable roles in the developing and mature
brain by regulating neuronal migration and differentiation, neurite outgrowth, axonal …

Stress‐inducible phosphoprotein 1 (STI1) is part of the chaperone machinery, but it also
functions as an extracellular ligand for the prion protein. However, the physiological …

The prion protein (PrP C) has been suggested to operate as a scaffold/receptor protein in
neurons, participating in both physiological and pathological associated events. PrP C …

Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a
group of fatal neurodegenerative disorders affecting humans and other mammalian species …

Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein
most abundantly found in the outer leaflet of the plasma membrane (PM) in the central …

Abstract The Hsp70/Hsp90 organising protein (Hop), also known as stress-inducible protein
1 (STI1), has received considerable attention for diverse cellular functions in both healthy …