The complexity of the intrarenal renin-angiotensin (Ang) system (RAS) continues to reveal
itself as evidence accumulates demonstrating its robust independent regulation in the …

Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase capable of
metabolizing angiotensin (Ang) II into Ang 1 to 7. We hypothesized that ACE2 is a negative …

688 Hypertension October 2017 clinical patterns of HIRD susceptibility schematically
illustrated in Figure 1 with respect to the BP threshold for HIRD and the slopes of the …

The microcirculation is a portion of the vascular circulatory system that consists of resistance
arteries, arterioles, capillaries and venules. It is the place where gases and nutrients are …

NADPH oxidase has been implicated in ANG II-induced oxidative stress and hypertension in
males; however, the contribution of oxidative stress to ANG II hypertension in females is …

Background: Naringenin, a member of the dihydroflavone family, has been shown to have a
protective function in multiple diseases. We previously demonstrated that naringenin played …

Abstract Aims: Exercise training (ExT) is a recommended adjunct to many pharmaceutical
antihypertensive therapies. The effects of chronic ExT on the development of hypertension …

Various stimuli, including hormones and growth factors, modulate epithelial sodium
channels (ENaCs), which fine-tune Na+ absorption in the kidney. Members of the EGF family …

Background Metabolic syndrome (MetS) is characterized by a cluster of health factors that
indicate a higher risk for cardio-renal diseases. Recent evidence indicates that antioxidants …