Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in
response to stress. This response also involves other distinct morphological and intracellular …

Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …

Pharmacologically active compounds that manipulate cellular senescence (senotherapies)
have recently shown great promise in multiple pre-clinical disease models, and some of …

Cell therapies represent a rapidly emerging class of new therapeutics. They are intended
and developed for the treatment of some of the most prevalent human diseases, including …

Senescence is a form of irreversible cell cycle arrest. Senescence plays a dual role in
cancer, as both a tumor suppressor by preventing the growth of damaged cells and a cancer …