Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Metabolic reprogramming is a hallmark of cancer development, progression, and
metastasis. Several metabolic pathways such as glycolysis, tricarboxylic acid (TCA) cycle …

Background Mitochondria play central roles in metabolic diseases including nonalcoholic
steatohepatitis (NASH). However, how mitochondria regulate NASH progression remains …

Background Glutaminolysis is a critical metabolic process that promotes cancer cell
proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of …

Metabolic reprogram is crucial to support cancer cell growth and movement as well as
determine cell fate. Mitochondrial protein acetylation regulates mitochondrial metabolism …

Cancer is the second leading cause of death, and incidences are increasing globally.
Simply defined, cancer is the uncontrolled proliferation of a cell, and depending on the …

Vascular endothelial injury initiates atherosclerosis (AS) progression. N-Acetylneuraminic
acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage …

Simple Summary Glutaminase GLS2 is an enzyme that metabolizes glutamine, one of the
main sources of energy and building blocks in tumor cells. In some types of cancer, this …

Background The pulmonary surfactant that lines the air–liquid surface within alveoli is a
protein–lipid mixture essential for gas exchange. Surfactant lipids and proteins are …

The mechanisms orchestrating recycling of lysosomes through autophagic lysosome
reformation (ALR) is incompletely understood. Previous data show that genetic depletion of …