The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

The electrocardiogram (ECG) empowered clinician scientists to measure the electrical
activity of the heart noninvasively to identify arrhythmias and heart disease. Shortly after the …

Obesity is a major risk factor for the development of life-threatening malignant ventricular
tachyarrhythmias (VT) and sudden cardiac death (SCD). Risks may be highest for patients …

Aims While variants in KCNQ1 are the commonest cause of the congenital long QT
syndrome, we and others find only a small I Ks in cardiomyocytes from human-induced …

The I Ks current has an established role in cardiac action potential repolarization, and
provides a repolarization reserve at times of stress. The underlying channels are formed …

KCNQ1 is a pore-forming K+ channel subunit critically important to cardiac repolarization at
high heart rates.(2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl) sulfonyl]-2 …

Background Genotype-positive patients who suffer from the cardiac channelopathy Long QT
Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown …

The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium
current, IKs, that responds to sympathetic stimulation and is critical for human cardiac …

G‐protein‐gated inwardly rectifying K+ (GIRK; Kir3. x) channels play important physiological
roles in various organs. Some of the disease‐associated mutations of GIRK channels are …

Abstract The cardiac KCNQ1+ KCNE1 (IKs) channel regulates heart rhythm under both
normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the …