▪ Abstract A vast number of proteins are involved in synaptic function. Many have been
cloned and their functional role defined with varying degrees of success, but their number …

At synapses throughout the brain and spinal cord, the amino-acid glutamate is the major
excitatory neurotransmitter. During evolution, a family of glutamate-receptor ion channels …

Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo
state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full …

Ionotropic glutamate receptors (iGluRs) mediate excitatory synaptic transmission in
vertebrates and invertebrates through ligand-induced opening of transmembrane ion …

Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory signaling in
the nervous system. Despite the profound importance of iGluRs to neurotransmission, little is …

Little is known about the molecular mechanisms underlying differences in the ligand binding
properties of AMPA, kainate, and NMDA subtype glutamate receptors. Crystal structures of …

Strategies for growing protein crystals have for many years been essentially empirical, the
protein, once purified to a certain homogeneity, being mixed with a selection of …

Structure and function of AMPA receptors - Gouaux - 2004 - The Journal of Physiology - Wiley
Online Library Skip to Article Content Skip to Article Information The Physiological Society The …

The location and number of neurotransmitter receptors are dynamically regulated at
postsynaptic sites. However, currently available methods for visualizing receptor trafficking …

NR3A is expressed widely in the developing CNS of mammals. Coassembly of NR3A with
NR1 and NR2 modifies NMDA receptor-mediated responses, reducing calcium permeability …