The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology,
being well suited to both developmental and genetic analysis. Large-scale genetic screens …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

INTRODUCTION During embryogenesis, pluripotent cells gradually become specialized
and acquire distinct functions and morphologies. Because much of the specification process …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have
essential physiological roles in mature organisms. Here we describe the first known small …

Vertebrate gastrulation involves the specification and coordinated movement of large
populations of cells that give rise to the ectodermal, mesodermal and endodermal germ …

Neural induction represents the earliest step in the determination of ectodermal cell fates. In
vertebrates, bone morphogenetic proteins (BMPs) act as signals of epidermal induction. The …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …