Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

A common need for microbial cells is the ability to respond to potentially toxic environmental
insults. Here we review the progress in understanding the response of the yeast …

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal
subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

The ribosome decoding center is rich in modified rRNA nucleotides and little is known about
their effects. Here, we examine the consequences of systematically deleting eight …

Ribosome assembly in eukaryotes requires approximately 200 essential assembly factors
(AFs) and occurs through ordered events that initiate in the nucleolus and culminate in the …

Ribosome assembly is required for cell growth in all organisms. Classic in vitro work in
bacteria has led to a detailed understanding of the biophysical, thermodynamic, and …

Many RNA nucleases and helicases participate in ribosome biogenesis, but how they
cooperate with each other is largely unknown. Here we report that in vivo cleavage of the …