Cerebral malaria in mouse and man

N Ghazanfari, SN Mueller, WR Heath - Frontiers in immunology, 2018 - frontiersin.org
Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite
Plasmodium falciparum, which develops in a small minority of infected patients and is …

Severe malaria: what's new on the pathogenesis front?

SC Wassmer, GER Grau - International journal for parasitology, 2017 - Elsevier
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

CD8+ T cells target cerebrovasculature in children with cerebral malaria

BA Riggle, M Manglani, D Maric… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Cerebral malaria (CM) accounts for nearly 400,000 deaths annually in
African children. Current dogma suggests that CM results from infected RBC (iRBC) …

The immunological balance between host and parasite in malaria

K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

JB De Souza, JCR Hafalla, EM Riley, KN Couper - Parasitology, 2010 - cambridge.org
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of
cerebral malaria is poorly defined and progress in understanding the condition is severely …

Human cerebral malaria and the blood–brain barrier

IM Medana, GDH Turner - International journal for parasitology, 2006 - Elsevier
Malaria represents a continuing and major global health challenge and our understanding
of how the Plasmodium parasite causes severe disease and death remains poor. One …

Cerebral malaria: mysteries at the blood-brain barrier

L Rénia, SW Howland, C Claser, AC Gruner… - Virulence, 2012 - Taylor & Francis
Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium
falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined …

Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice

H Li, N Zhang, HY Lin, Y Yu, QY Cai, L Ma, S Ding - BMC neuroscience, 2014 - Springer
Background Following the onset of focal ischemic stroke, the brain experiences a series of
alterations including infarct evolvement, cellular proliferation in the penumbra, and …

Immunopathogenesis of cerebral malaria

NH Hunt, J Golenser, T Chan-Ling, S Parekh… - International journal for …, 2006 - Elsevier
Malaria is one of the most important global health problems, potentially affecting more than
one third of the world's population. Cerebral malaria (CM) is a deadly complication of …

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

PA Swanson, GT Hart, MV Russo, D Nayak… - PLoS …, 2016 - journals.plos.org
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …