Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic
lateral sclerosis has been intensively studied. However, the origin of these disorders …

Abstract" Serum ferritin" presents a paradox, as the iron storage protein ferritin is not
synthesised in serum yet is to be found there. Serum ferritin is also a well known …

Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs
in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by cortical and spinal motor neuron dysfunction. Routine magnetic resonance …

Objective Previous studies have reported distinct serological profiles of lipid, urate and
ferritin in Western patients with amyotrophic lateral sclerosis (ALS). We aimed to examine …

In this article, we review the original findings from MRI and autopsy studies that
demonstrated brain iron status is insufficient in individuals with restless legs syndrome …

Abstract Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of
cellular pathways that are fundamental for brain function, including neurotransmitter …

Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for
several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the …

Iron accumulation in the brain and increased oxidative stress are consistent observations in
many neurodegenerative diseases. Thus, we have begun examination into gene mutations …