Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Background Whereas heart failure with reduced ejection fraction (HFrEF) is associated with
ventricular dilation and markedly reduced systolic function, heart failure with preserved …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

The sarcoplasmic reticulum (SR) plays the key role in cardiac function as the major source of
Ca2+ that activates cardiomyocyte contractile machinery. Disturbances in finely-tuned SR …

Heart failure with preserved ejection fraction (HFpEF) is defined by increased left ventricular
(LV) stiffness, impaired vascular compliance, and fibrosis. Although systemic inflammation …

Heart failure (HF) is a heterogeneous condition that can be categorized according to the left
ventricular ejection fraction (EF) into HF with reduced (HFrEF) or preserved (HFpEF) EF …

Heart failure (HF) is a major deteriorating disease of the myocardium due to weak
myocardial muscles. As such, the heart is unable to pump blood efficiently around the body …

Ferroptosis is a recently identified cell death characterized by an excessive accumulation of
iron-dependent reactive oxygen species (ROS) and lipid peroxides. Intracellular iron …