Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Non-resolving inflammation drives the development of clinically dangerous atherosclerotic
lesions by promoting sustained plaque inflammation, large necrotic cores, thin fibrous caps …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Background—Inflammation and activation of immune cells are key mechanisms in the
development of atherosclerosis. Previous data indicate important roles for monocytes and T …

Insulin resistance results from several pathophysiologic mechanisms, including chronic
tissue inflammation and defective insulin signaling. We found that liver, muscle and adipose …

Atherosclerosis is commonly looked upon as a chronic inflammatory disease of the arterial
wall arising from an unbalanced lipid metabolism and a maladaptive inflammatory response …

Acute inflammation is a host-protective response that is mounted in response to tissue injury
and infection. Initiated and perpetuated by exogenous and endogenous mediators, acute …

Essential fatty acids (EFAs), linoleic acid (LA), and α‐linolenic acid (ALA) are essential for
humans, and are freely available in the diet. Hence, EFA deficiency is extremely rare in …