Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
View from the heart: cardiac fibroblasts in development, scarring and regeneration
MB Furtado, HT Nim, SE Boyd… - Development, 2016 - journals.biologists.com
In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …
tissue integrity with scar formation but does not restore normal architecture and function. The …
[HTML][HTML] Disease model of GATA4 mutation reveals transcription factor cooperativity in human cardiogenesis
YS Ang, RN Rivas, AJS Ribeiro, R Srivas, J Rivera… - Cell, 2016 - cell.com
Mutation of highly conserved residues in transcription factors may affect protein-protein or
protein-DNA interactions, leading to gene network dysregulation and human disease …
protein-DNA interactions, leading to gene network dysregulation and human disease …
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease
To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …
development, we generated single-cell chromatin accessibility maps of human fetal heart …
The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation
Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of
cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we …
cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we …
Of mice and men: molecular genetics of congenital heart disease
TA Andersen, KLL Troelsen, LA Larsen - Cellular and molecular life …, 2014 - Springer
Congenital heart disease (CHD) affects nearly 1% of the population. It is a complex disease,
which may be caused by multiple genetic and environmental factors. Studies in human …
which may be caused by multiple genetic and environmental factors. Studies in human …
[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications
J Yasuhara, V Garg - Translational Pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …
leading cause of mortality in childhood. Although advances in clinical management have …
[HTML][HTML] Paternal preconception phthalate exposure alters sperm methylome and embryonic programming
Preconception environmental conditions have been demonstrated to shape sperm
epigenetics and subsequently offspring health and development. Our previous findings in …
epigenetics and subsequently offspring health and development. Our previous findings in …
[HTML][HTML] Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease
(CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in …
(CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in …
Utilization of whole exome sequencing to identify causative mutations in familial congenital heart disease
Background—Congenital heart disease (CHD) is the most common type of birth defect with
family-and population-based studies supporting a strong genetic cause for CHD. The goal of …
family-and population-based studies supporting a strong genetic cause for CHD. The goal of …