TUNEL assay: a powerful tool for kidney injury evaluation

CL Moore, AV Savenka, AG Basnakian - International journal of molecular …, 2021 - mdpi.com
Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay is a long-
established assay used to detect cell death-associated DNA fragmentation (3'-OH DNA …

Is aberrant reno-renal reflex control of blood pressure a contributor to chronic intermittent hypoxia-induced hypertension?

S AlMarabeh, MH Abdulla, KD O'Halloran - Frontiers in physiology, 2019 - frontiersin.org
Renal sensory nerves are important in the regulation of body fluid and electrolyte
homeostasis, and blood pressure. Activation of renal mechanoreceptor afferents triggers a …

Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway

J Si, B Liu, K Qi, X Chen, D Li, S Yang, E Ji - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Chronic intermittent hypoxia (CIH) is the primary
pathophysiological process of obstructive sleep apnea (OSA) and is closely linked to …

Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation

C Arnaud, E Billoir, AF de Melo Junior… - The Journal of …, 2023 - Wiley Online Library
Chronic intermittent hypoxia (CIH) is the dominant pathological feature of human obstructive
sleep apnoea (OSA), which is highly prevalent and associated with cardiovascular and renal …

Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis

P Guan, ZM Sun, LF Luo, J Zhou, S Yang, YS Zhao… - Life sciences, 2019 - Elsevier
Aims Hydrogen gas (H 2) has a diversity of effects such as anti-apoptotic, anti-inflammatory
and anti-oxidative properties. However, molecular mechanism underlying the potential effect …

Intermittent hypoxia-induced autophagy via AMPK/mTOR signaling pathway attenuates endothelial apoptosis and dysfunction in vitro

H Guo, H Ding, Y Yan, Q Chen, J Zhang, B Chen… - Sleep and …, 2021 - Springer
Purpose The aim of this study was to examine whether or not intermittent hypoxia (IH)
upregulated autophagy and the contributions of autophagy to endothelial apoptosis and …

[HTML][HTML] Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea model

XB Zhang, HJ Cheng, YT Yuan, Y Chen… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea (OSA), is
associated with various cardiovascular diseases. In the present study, we assessed the …

Hydrogen gas alleviates chronic intermittent hypoxia-induced renal injury through reducing iron overload

P Guan, ZM Sun, LF Luo, YS Zhao, SC Yang, FY Yu… - Molecules, 2019 - mdpi.com
Iron-induced oxidative stress has been found to be a central player in the pathogenesis of
kidney injury. Recent studies have indicated H2 can be used as a novel antioxidant to …

Transcriptional activation of PINK1 by MyoD1 mediates mitochondrial homeostasis to induce renal calcification in pediatric nephrolithiasis

K Zhang, X Fang, Y Zhang, Y Zhang, M Chao - Cell Death Discovery, 2024 - nature.com
This study aims to uncover the molecular mechanisms underlying pediatric kidney stone
formation induced by renal calcium deposition by utilizing high-throughput sequencing data …

Chronic intermittent hypoxia induces renal fibrosis through MR activation

CJ Zhang, H Li, YZ Xiong, Y Chang, F Yang… - Experimental …, 2022 - Elsevier
Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by recurrent arousal
from sleep and chronic intermittent hypoxia (CIH). OSAS-associated chronic kidney disease …