Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents

T Luger, M Amagai, B Dreno, MA Dagnelie… - Journal of …, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by eczematous
and pruritic skin lesions. In recent decades, the prevalence of AD has increased worldwide …

Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches

DYM Leung, E Guttman-Yassky - Journal of Allergy and Clinical …, 2014 - Elsevier
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often
precedes the development of food allergy and asthma. Recent insights into AD reveal …

Dissecting the formation, structure and barrier function of the stratum corneum

T Matsui, M Amagai - International immunology, 2015 - academic.oup.com
The skin is the largest organ of the mammalian body. The outermost layer of mammalian
skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that …

Genetic and epigenetic studies of atopic dermatitis

L Bin, DYM Leung - Allergy, Asthma & Clinical Immunology, 2016 - Springer
Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex
interaction of genetic, immune and environmental factors. There have many recent …

Bacterial and viral infections in atopic dermatitis: a comprehensive review

PY Ong, DYM Leung - Clinical reviews in allergy & immunology, 2016 - Springer
Atopic dermatitis (AD) is the most common allergic skin disease in the general population. It
is a chronic inflammatory skin disease complicated by recurrent bacterial and viral infections …

Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis

JP Thyssen, S Kezic - Journal of Allergy and Clinical Immunology, 2014 - Elsevier
The epidermis protects human subjects from exogenous stressors and helps to maintain
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is …

Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

G Egawa, K Kabashima - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models …

The itch–scratch cycle: a neuroimmune perspective

MR Mack, BS Kim - Trends in immunology, 2018 - cell.com
Relentless, repetitive itching and scratching is a debilitating feature of many chronic
inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch …

Barrier dysfunction in the skin allergy

G Egawa, K Kabashima - Allergology international, 2018 - jstage.jst.go.jp
abstract The skin is continuously exposed to external pathogens, and its barrier function is
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …

The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis

A Otsuka, T Nomura, P Rerknimitr… - Immunological …, 2017 - Wiley Online Library
Atopic dermatitis (AD) is a chronic skin disorder characterized by pruritus and recurrent
eczematous lesions that are accompanied by T‐helper (Th) 2‐dominated inflammation. AD …