T lymphocytes equipped with clonotypic T cell antigen receptors (TCR) recognize
immunogenic peptides only when presented in the context of their own major …

After a long period where the potential of therapeutic peptides was let into oblivion and even
dismissed, there is a revival of interest in peptides as potential drug candidates. Novel …

TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen
specificity. However, there are substantial variations in the cell surface expression levels of …

Autoreactive CD8+ T lymphocytes play a key role in the pathogenesis of several
autoimmune diseases. It is not yet well understood how autoreactive CD8+ T cells, which …

CD40 and CD40 ligand (CD40L) are costimulatory molecules that play a pivotal role in the
proinflammatory immune response. Primarily expressed by activated CD4+ T cells, CD40L …

XIncreasing evidence supports a role for CD8+ T cells in multiple sclerosis. In an attempt to
isolate the contribution of CD8+ T cells in a murine model of MS, we immunized mice with a …

Exposure of naive CD8 T cells to the synergistic combination of interleukin (IL)‐7 and IL‐21
enables them to respond strongly to subsequent antigen stimulation. Mechanisms …

T cell recognition of antigen is a crucial aspect of the adaptive immune response. One of the
most common means of pathogen immune evasion is mutation of T cell epitopes. T cell …

Activation of T cells by agonistic peptide-MHC can be inhibited by antagonistic ones.
However, the exact mechanism remains elusive. We used Jurkat cells expressing two …

The functional outcomes of the T cell's interaction with the peptide: MHC complex can be
dramatically altered by the introduction of a single amino acid substitution. Previous studies …