[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy

A Rakotomalala, A Escande, A Furlan… - Frontiers in …, 2021 - frontiersin.org
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …

Hypoxia-induced cancer cell responses driving radioresistance of hypoxic tumors: approaches to targeting and radiosensitizing

AE Kabakov, AO Yakimova - Cancers, 2021 - mdpi.com
Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Y Wei, Y Li, Y Chen, P Liu, S Huang, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

[HTML][HTML] Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells–a potential contribution to the predictive, preventive …

A Mazurakova, L Koklesova, SH Csizmár… - Journal of Advanced …, 2024 - Elsevier
Background Cancer management faces multiple obstacles, including resistance to current
therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt …

Cellular and molecular biology of cancer stem cells of hepatocellular carcinoma

KS Jeng, CF Chang, IS Sheen, CJ Jeng… - International journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death globally. The
cancer stem cells (CSCs) of HCC are responsible for tumor growth, invasion, metastasis …

[PDF][PDF] Integration of glucose and cardiolipin anabolism confers radiation resistance of HCC

Y Fang, Y Zhan, Y Xie, S Du, Y Chen, Z Zeng… - …, 2022 - Wiley Online Library
Abstract Background and Aims Poor response to ionizing radiation (IR) due to resistance
remains a clinical challenge. Altered metabolism represents a defining characteristic of …

Biological adaptations of tumor cells to radiation therapy

A Carlos-Reyes, MA Muñiz-Lino… - Frontiers in …, 2021 - frontiersin.org
Radiation therapy has been used worldwide for many decades as a therapeutic regimen for
the treatment of different types of cancer. Just over 50% of cancer patients are treated with …

PDK1 inhibitor BX795 improves cisplatin and radio-efficacy in oral squamous cell carcinoma by downregulating the PDK1/CD47/Akt-mediated glycolysis signaling …

S Pai, VK Yadav, KT Kuo, NW Pikatan, CS Lin… - International journal of …, 2021 - mdpi.com
Background: Oral squamous cell carcinoma (OSCC) has a high prevalence and predicted
global mortality rate of 67.1%, necessitating better therapeutic strategies. Moreover, the …

Induction of mastitis by cow-to-mouse fecal and milk microbiota transplantation causes microbiome dysbiosis and genomic functional perturbation in mice

MN Hoque, MS Rahman, T Islam, M Sultana… - Animal microbiome, 2022 - Springer
Background Mastitis pathogenesis involves a wide range of opportunistic and apparently
resident microorganims including bacteria, viruses and archaea. In dairy animals, microbes …