True gene silencing
M Nashimoto - International Journal of Molecular Sciences, 2022 - mdpi.com
TRUE gene silencing is an RNA-mediated gene expression control technology and is
termed after tRNase ZL-utilizing efficacious gene silencing. In this review, I overview the …
termed after tRNase ZL-utilizing efficacious gene silencing. In this review, I overview the …
Potential Small Guide RNAs for tRNase ZL from Human Plasma, Peripheral Blood Mononuclear Cells, and Cultured Cell Lines
S Ninomiya, M Kawano, T Abe, T Ishikawa… - PLoS …, 2015 - journals.plos.org
Several pieces of evidence suggest that small RNA degradation products together with
tRNase ZL appear to form another layer of the whole gene regulatory network. The …
tRNase ZL appear to form another layer of the whole gene regulatory network. The …
Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing
S Iizuka, N Oridate, M Nashimoto, S Fukuda… - PLOS …, 2014 - journals.plos.org
Head and neck squamous cell carcinoma (HNSCC) exhibits increased expression of cyclin
D1 (CCND1). Previous studies have shown a correlation between poor prognosis of …
D1 (CCND1). Previous studies have shown a correlation between poor prognosis of …
TRUE gene silencing: screening of a heptamer-type small guide RNA library for potential cancer therapeutic agents
A Haino, T Ishikawa, M Seki… - Journal of Visualized …, 2016 - pmc.ncbi.nlm.nih.gov
TRUE gene silencing (termed after tRNase ZL-utilizing efficacious gene silencing) is one of
the RNA-directed gene silencing technologies, which utilizes an artificial small guide RNA …
the RNA-directed gene silencing technologies, which utilizes an artificial small guide RNA …
Cleavage of MALAT1 RNA by 14-nt sgRNA-guided tRNase ZL
M Takahashi, M Nashimoto - bioRxiv, 2025 - biorxiv.org
We have been developing a gene suppression technology, tRNase ZL-utilizing efficacious
(TRUE) gene silencing, in which artificially designed small guide RNA (sgRNA) guides …
(TRUE) gene silencing, in which artificially designed small guide RNA (sgRNA) guides …
Evaluation of double heptamer-type sgRNA as a potential therapeutic agent against multiple myeloma
T Ishikawa, A Haino, T Ichiyanagi, M Seki… - Blood Cells, Molecules …, 2019 - Elsevier
Emergence of drug-resistant mutations in the course of myeloma cell evolution and
subsequent relapse of myeloma appears to be currently inevitable in most patients. To …
subsequent relapse of myeloma appears to be currently inevitable in most patients. To …
Heptamer-type small guide RNA that can shift macrophages toward the M1 state
T Ishikawa, A Haino, T Ichiyanagi, M Takahashi… - Blood Cells, Molecules …, 2021 - Elsevier
Multiple myeloma is a refractory cancer of plasma cells. Although treatment strategies for
multiple myeloma are getting improved year by year, in most cases patients relapse due to …
multiple myeloma are getting improved year by year, in most cases patients relapse due to …
The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression
T Nozaki, M Takahashi, T Ishikawa, A Haino… - … and Biophysics Reports, 2021 - Elsevier
TRUE gene silencing is one of the gene suppression technologies. This technology exploits
the enzymatic property of the tRNA 3′ processing endoribonuclease tRNase ZL, which is …
the enzymatic property of the tRNA 3′ processing endoribonuclease tRNase ZL, which is …
Small guide antisense nucleic acid and use thereof
孝上村， 正之， 梨本， 慎吾， 中村， 玲金 - 2019 - Google Patents
The present invention relates to providing a nucleic acid medicine for managing a disease
or disorder related to unwanted gene expression. More specifically, the inventors of the …
or disorder related to unwanted gene expression. More specifically, the inventors of the …
TRUE gene silencing 法を基盤とした
石川達矢 - nupals.repo.nii.ac.jp
要約多発性骨髄腫は, 形質細胞の難治性のがんである. 多発性骨髄腫の治療戦略は
年々改善されているが, ほとんどの場合, 薬剤耐性変異の出現により再発してしまう …
年々改善されているが, ほとんどの場合, 薬剤耐性変異の出現により再発してしまう …