Multiple sclerosis: risk factors, prodromes, and potential causal pathways

SV Ramagopalan, R Dobson, UC Meier… - The Lancet …, 2010 - thelancet.com
Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …

Vitamin D and genetic susceptibility to multiple sclerosis

C Scazzone, L Agnello, G Bivona, B Lo Sasso… - Biochemical …, 2021 - Springer
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system
(CNS), resulting from the interaction among genetic, epigenetic, and environmental factors …

Environmental factors and their timing in adult-onset multiple sclerosis

AE Handel, G Giovannoni, GC Ebers… - Nature Reviews …, 2010 - nature.com
Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data
implicate both genetic and environmental factors in the etiology of MS, with various factors …

Epidemiology of multiple sclerosis

SV Ramagopalan, AD Sadovnick - Neurologic clinics, 2011 - neurologic.theclinics.com
Multiple sclerosis (MS) is the most common disease of the central nervous system that
causes permanent disability in young adults. 1 Based on strong circumstantial evidence, MS …

Sexual differentiation of the rodent brain: dogma and beyond

KM Lenz, BM Nugent, MM McCarthy - Frontiers in neuroscience, 2012 - frontiersin.org
Steroid hormones of gonadal origin act on the neonatal brain to produce sex differences that
underlie adult reproductive physiology and behavior. Neuronal sex differences occur on a …

Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms

JM Greer, PA McCombe - Journal of neuroimmunology, 2011 - Elsevier
Multiple sclerosis (MS) is more prevalent in females than males, and this female
predominance is increasing as time goes by. Additionally, gender appears to play critical …

Is multiple sclerosis an autoimmune disease?

B Wootla, M Eriguchi, M Rodriguez - Autoimmune diseases, 2012 - Wiley Online Library
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) with varied clinical presentations and heterogeneous histopathological …

Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression

RR Voskuhl, AH Sawalha, Y Itoh - Multiple Sclerosis Journal, 2018 - journals.sagepub.com
Background: Why are women more susceptible to multiple sclerosis, but men have worse
disability progression? Sex differences in disease may be due to sex hormones, sex …

Effect of gender on late-onset multiple sclerosis

RM Bove, B Healy, A Augustine… - Multiple Sclerosis …, 2012 - journals.sagepub.com
Objectives: We aimed to examine the incidence and disease course of late-onset multiple
sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based …

Environmental factors in multiple sclerosis: epstein‐Barr virus, vitamin D, and cigarette smoking

DM Wingerchuk - Mount Sinai Journal of Medicine: A Journal …, 2011 - Wiley Online Library
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system.
Although its cause is not known, genetic and environmental factors both influence …