Mechanism of membrane fusion: interplay of lipid and peptide

A Joardar, GP Pattnaik, H Chakraborty - The Journal of Membrane Biology, 2022 - Springer
Membrane fusion is an essential process for the survival of eukaryotes and the entry of
enveloped viruses into host cells. A proper understanding of the mechanism of membrane …

Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

Phosphatidylethanolamine and cholesterol promote hemifusion formation: A tug of war between membrane interfacial order and intrinsic negative curvature of lipids

S Mishra, H Chakraborty - The Journal of Physical Chemistry B, 2023 - ACS Publications
Membrane fusion is an important process for the survival of eukaryotes. The shape of lipids
plays an important role in fusion by stabilizing nonlamellar fusion intermediates. Lipids with …

The three lives of viral fusion peptides

B Apellániz, N Huarte, E Largo, JL Nieva - Chemistry and physics of lipids, 2014 - Elsevier
Fusion peptides comprise conserved hydrophobic domains absolutely required for the
fusogenic activity of glycoproteins from divergent virus families. After 30 years of intensive …

Membrane composition modulates fusion by altering membrane properties and fusion peptide structure

G Meher, H Chakraborty - The Journal of membrane biology, 2019 - Springer
Membrane fusion, one of the most essential processes in the life of eukaryotes, occurs when
two separate lipid bilayers merge into a continuous bilayer and internal contents of two …

Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics

H Chakraborty, S Bhattacharjya - Biophysical Chemistry, 2020 - Elsevier
The emerging and re-emerging viral diseases are continuous threats to the wellbeing of
human life. Previous outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle …

The local variation of the Gaussian modulus enables different pathways for fluid lipid vesicle fusion

M Bottacchiari, M Gallo, M Bussoletti, CM Casciola - Scientific Reports, 2024 - nature.com
Viral infections, fertilization, neurotransmission, and many other fundamental biological
processes rely on membrane fusion. Straightforward calculations based on the celebrated …

SARS-CoV fusion peptides induce membrane surface ordering and curvature

LGM Basso, EF Vicente, E Crusca Jr, EM Cilli… - Scientific reports, 2016 - nature.com
Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral
fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory …

Leaflet by leaflet synergistic effects of antimicrobial peptides on bacterial and mammalian membrane models

A Roy, NK Sarangi, S Ghosh… - The Journal of …, 2023 - ACS Publications
Antimicrobial peptides (AMPs) offer significant hope in the fight against antibiotic resistance.
Operating via a mechanism different from that of antibiotics, they target the microbial …

Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms

A Pabis, RJ Rawle, PM Kasson - Proceedings of the …, 2020 - National Acad Sciences
Enveloped viruses enter cells via a process of membrane fusion between the viral envelope
and a cellular membrane. For influenza virus, mutational data have shown that the …