The emerging role of lysophosphatidic acid in cancer
GB Mills, WH Moolenaar - Nature Reviews Cancer, 2003 - nature.com
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation,
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
H Rosen, EJ Goetzl - Nature Reviews Immunology, 2005 - nature.com
Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …
transmits signals through a family of G-protein-coupled receptors to control cellular …
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate
Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …
Crystal structure of a lipid G protein–coupled receptor
The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking,
endothelial development and integrity, heart rate, and vascular tone and maturation by …
endothelial development and integrity, heart rate, and vascular tone and maturation by …
[HTML][HTML] Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development
During angiogenesis, nascent vascular sprouts fuse to form vascular networks, enabling
efficient circulation. Mechanisms that stabilize the vascular plexus are not well understood …
efficient circulation. Mechanisms that stabilize the vascular plexus are not well understood …
Crystal structure of antagonist bound human lysophosphatidic acid receptor 1
JE Chrencik, CB Roth, M Terakado, H Kurata, R Omi… - Cell, 2015 - cell.com
Lipid biology continues to emerge as an area of significant therapeutic interest, particularly
as the result of an enhanced understanding of the wealth of signaling molecules with …
as the result of an enhanced understanding of the wealth of signaling molecules with …
G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
SM Pasternack, I von Kügelgen, KA Aboud, YA Lee… - Nature …, 2008 - nature.com
Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an
autosomal recessive form of this disorder to chromosome 13q14. 11–13q21. 33, and …
autosomal recessive form of this disorder to chromosome 13q14. 11–13q21. 33, and …
International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P),
are now recognized as important extracellular signaling molecules. These lipid mediators …
are now recognized as important extracellular signaling molecules. These lipid mediators …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Sphingosine-1-phosphate and its receptors: structure, signaling, and influence
The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …