Hyperpolarized 129Xe MRI of the human lung

JP Mugler III, TA Altes - Journal of Magnetic Resonance …, 2013 - Wiley Online Library
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

NMR hyperpolarization techniques of gases

DA Barskiy, AM Coffey, P Nikolaou… - … A European Journal, 2017 - Wiley Online Library
Nuclear spin polarization can be significantly increased through the process of
hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance …

Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI

H Li, X Zhao, Y Wang, X Lou, S Chen, H Deng… - Science …, 2021 - science.org
The recovery process of COVID-19 patients is unclear. Some recovered patients complain of
continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the …

NMR hyperpolarization techniques for biomedicine

P Nikolaou, BM Goodson… - Chemistry–A European …, 2015 - Wiley Online Library
Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo
molecular imaging modalities, ranging from functional imaging of the lungs to metabolic …

Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe …

PJ Niedbalski, CS Hall, M Castro… - Magnetic resonance …, 2021 - Wiley Online Library
Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Hyperpolarized 3He and 129Xe MR Imaging in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease

M Kirby, S Svenningsen, A Owrangi, A Wheatley… - Radiology, 2012 - pubs.rsna.org
Purpose To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129 (129Xe)
magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and …

Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis

JM Wang, SH Robertson, Z Wang, M He, RS Virgincar… - Thorax, 2018 - thorax.bmj.com
Background Assessing functional impairment, therapeutic response and disease
progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging …

[HTML][HTML] Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients

RP Thomen, LL Walkup, DJ Roach, ZI Cleveland… - Journal of Cystic …, 2017 - Elsevier
Background Cystic fibrosis (CF) is a genetic disease which carries high morbidity and
mortality from lung-function decline. Monitoring disease progression and treatment response …

Hyperpolarized 3He and 129Xe MRI: Differences in asthma before bronchodilation

S Svenningsen, M Kirby, D Starr… - Journal of magnetic …, 2013 - Wiley Online Library
Purpose To compare hyperpolarized helium‐3 (3He) and xenon‐129 (129Xe) MRI in
asthmatics before and after salbutamol inhalation. Materials and Methods Seven asthmatics …

Single‐breath clinical imaging of hyperpolarized 129xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1‐point Dixon acquisition

SS Kaushik, SH Robertson… - Magnetic resonance …, 2016 - Wiley Online Library
Purpose We sought to develop and test a clinically feasible 1‐point Dixon, three‐
dimensional (3D) radial acquisition strategy to create isotropic 3D MR images of 129Xe in …