The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Abstract Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA
copy of their genome after entry into the host cell. Integration of this DNA into the host cell's …

The HIV-1 core consists of capsid proteins (CA) surrounding viral genomic RNA. After virus-
cell fusion, the core enters the cytoplasm and the capsid shell is lost through uncoating. CA …

During the last two decades, the profusion of HIV research due to the urge to identify new
therapeutic targets has led to a wealth of information on the retroviral replication cycle …

Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …

Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1
integrase (IN) in human cells. We have determined the NMR structure of the integrase …

We have previously shown that the p75 isoform of the transcriptional co-activator lens
epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency …

Transcriptional co-activator LEDGF/p75 is the major cellular interactor of HIV-1 integrase
(IN), critical to efficient viral replication. In this work, a series of INs from the Betaretrovirus …

The transcriptional coactivator lens epithelium-derived growth factor (LEDGF)/p75 acts as a
chromatin tethering factor for human immunodeficiency virus type 1 (HIV-1) integrase …

HIV integrates a DNA copy of its genome into a host cell chromosome in each replication
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …