In systemic sclerosis (SSc), abnormalities in microvessel morphology occur early and evolve
into a distinctive vasculopathy that relentlessly advances in parallel with the development of …

A hallmark of disease pathogenesis of systemic sclerosis (SSc) is the presence of
autoreactive B cell responses targeting nuclear proteins. Almost all SSc-patients harbour …

Systemic sclerosis (SSc) is a complex autoimmune inflammatory disorder with multiple
organ involvement. Skin changes present the hallmark of SSc and coincide with poor …

Immune privilege is the ability to tolerate foreign antigens without eliciting an inflammatory
immune response. Several mechanisms explain a structure's immune privilege status, which …

摘要胰腺导管腺癌(pancreatic ductal adenocarcinoma, PDAC) 是世界范围内因癌症死亡的
主要原因之一, 目前临床上缺乏对PDAC 有效的筛查和治疗手段. 近十年来 …

Fibrosis can occur in almost every organ system. It can occur in single organs, such as in
idiopathic pulmonary fibrosis (IPF), or affect multiple organs as in systemic sclerosis (SSc) …

Objectives Little is known on the mechanisms necessary to maintain the physiological adult
human skin integrity. This study aims to quantitatively describe anatomical changes in …

ABSTRACT A hallmark of disease pathogenesis of systemic sclerosis (SSc) is the presence
of autoreactive B cell responses targeting nuclear proteins. Almost all SSc-patients harbour …