Computer-aided drug discovery/design methods have played a major role in the
development of therapeutically important small molecules for over three decades. These …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …

There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs)
regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular …

Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but
requires actin polymerization in others. We show that membrane tension determines the …

The signalling pathways utilised by insulin receptor (IR) and IGF receptor to transduce their
diverse effects on cellular metabolism, growth and survival are well established in broad …

Taking a strand: Aptamers are small single‐stranded oligonucleotides that fold into a well‐
defined 3D structure and interact with high affinity and specificity with their target molecules …