Cofilin and actin dynamics: multiple modes of regulation and their impacts in neuronal development and degeneration

JR Bamburg, LS Minamide, ON Wiggan… - Cells, 2021 - mdpi.com
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The MYO 6 interactome: selective motor‐cargo complexes for diverse cellular processes

JJ de Jonge, C Batters, T O'Loughlin, SD Arden… - FEBS …, 2019 - Wiley Online Library
Myosins of class VI (MYO 6) are unique actin‐based motor proteins that move cargo towards
the minus ends of actin filaments. As the sole myosin with this directionality, it is critically …

[HTML][HTML] Role of actin-binding proteins in the regulation of cellular mechanics

AV Vakhrusheva, AV Murashko, ES Trifonova… - European Journal of …, 2022 - Elsevier
The viscoelastic parameters of the cell can report on the cell state, cellular processes and
diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important …

Potential significance of serum autoantibodies to endometrial antigens, α-Enolase and hormones in non-invasive diagnosis and pathogenesis of endometriosis

IV Menzhinskaya, SV Pavlovich… - International Journal of …, 2023 - mdpi.com
The objective of the study was to evaluate the profile of serum autoantibodies and their
diagnostic and pathogenetic significance in ovarian endometrioma (OEM) and deep …

The role of Nα‐terminal acetylation in protein conformation

S Calis, K Gevaert - The FEBS Journal, 2024 - Wiley Online Library
Especially in higher eukaryotes, the N termini of proteins are subject to enzymatic
modifications, with the acetylation of the alpha‐amino group of nascent polypeptides being a …

Diversity from similarity: cellular strategies for assigning particular identities to actin filaments and networks

M Boiero Sanders, A Antkowiak… - Open Biology, 2020 - royalsocietypublishing.org
The actin cytoskeleton has the particularity of being assembled into many functionally
distinct filamentous networks from a common reservoir of monomeric actin. Each of these …

Myosin-1C differentially displaces tropomyosin isoforms altering their inhibition of motility

LW Pollard, M Boczkowska, R Dominguez… - Journal of Biological …, 2024 - jbc.org
Force generation and motility by actomyosin in nonmuscle cells are spatially regulated by∼
40 tropomyosin (Tpm) isoforms. The means by which Tpms are targeted to specific cellular …

Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms

EC Hardeman, NS Bryce, PW Gunning - Seminars in cell & developmental …, 2020 - Elsevier
The physiological function of actin filaments is challenging to dissect because of the
pleiotropic impact of global disruption of the actin cytoskeleton. Tropomyosin isoforms have …

Novel variants in GALE cause syndromic macrothrombocytopenia by disrupting glycosylation and thrombopoiesis

A Marín-Quílez, CA Di Buduo, L Díaz-Ajenjo… - Blood, 2023 - ashpublications.org
Glycosylation is recognized as a key process for proper megakaryopoiesis and platelet
formation. The enzyme uridine diphosphate (UDP)-galactose-4-epimerase, encoded by …

Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly

H Wioland, S Frémont, B Guichard, A Echard… - EMBO …, 2021 - embopress.org
Proteins of the ADF/cofilin family play a central role in the disassembly of actin filaments, and
their activity must be tightly regulated in cells. Recently, the oxidation of actin filaments by …