Genetics of inflammatory bowel diseases

DPB McGovern, S Kugathasan, JH Cho - Gastroenterology, 2015 - Elsevier
In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the …

[HTML][HTML] Enthesitis: new insights into pathogenesis, diagnostic modalities, and treatment

AS Kehl, M Corr, MH Weisman - Arthritis & rheumatology (Hoboken …, 2016 - ncbi.nlm.nih.gov
Enthesitis is a central feature of spondyloarthritis (SpA). Although enthesitis has traditionally
been considered to be a focal insertional disorder, advanced imaging and pathologic …

Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis

JD Reveille - Clinical rheumatology, 2015 - Springer
With the growing awareness of the impact of chronic back pain and axial spondyloarthritis
and recent breakthroughs in genetics and the development of novel treatments which may …

Perturbed mucosal immunity and dysbiosis accompany clinical disease in a rat model of spondyloarthritis

MJ Asquith, P Stauffer, S Davin, C Mitchell… - Arthritis & …, 2016 - Wiley Online Library
Objective The HLA–B27/β2‐microglobulin (β2m)–transgenic (Tg) rat is a leading model of
B27‐associated spondyloarthritis (SpA), and the disease is dependent on the presence of …

A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis

E Klingberg, H Strid, A Ståhl, A Deminger… - Arthritis research & …, 2017 - Springer
Background Patients with ankylosing spondylitis (AS) are at increased risk of developing
inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin …

Biomarker development for axial spondyloarthritis

MA Brown, Z Li, KAL Cao - Nature Reviews Rheumatology, 2020 - nature.com
The term axial spondyloarthritis (axSpA) encompasses a heterogeneous group of diseases
that have variable presentations, extra-articular manifestations and clinical outcomes, and …

SpA plus IBD or IBD plus SpA: Does commutative property apply?

F Carubbi, A Alunno, A Viscido, X Baraliakos… - Autoimmunity …, 2023 - Elsevier
The term spondyloarthritis (SpA) encompasses a group of interrelated disorders
characterised by the involvement of the musculoskeletal system as well as extra-articular …

Proton pump inhibitor use is associated with elevated faecal calprotectin levels. A cross-sectional study on subjects referred for colonoscopy

D Lundgren, V Eklöf, R Palmqvist… - Scandinavian journal …, 2019 - Taylor & Francis
Abstract Objectives: Faecal Calprotectin (FC) is a sensitive marker for gut inflammation.
However, slightly elevated FC levels are also common in subjects without inflammation. We …

Fecal calprotectin in systemic sclerosis and review of the literature

I Marie, AM Leroi, JF Menard, H Levesque… - Autoimmunity …, 2015 - Elsevier
Fecal calprotectin (FC) is a simple, non-invasive and reproducible test, which has been
described to be highly elevated in patients with active inflammatory bowel diseases …

HLA risk alleles and gut microbiome in ankylosing spondylitis and rheumatoid arthritis

H Xu, J Yin - Best Practice & Research Clinical Rheumatology, 2019 - Elsevier
Human leukocyte antigen (HLA) alleles are associated with a variety of autoimmune
diseases. The composition of gut microbiome can be influenced by host immunity, which is …